Key takeaways
- FDA-approved ED pills are relatively safe to take. You need to talk with a healthcare professional to avoid any potential side effects.
- Vardenafil (Levitra) is thought to have the least side effects. However, this can vary by person.
- In addition to drug safety, it’s important to make sure the online platform you buy ED meds from is legit to reduce the risk of complications.
Erectile dysfunction (ED) is not as uncommon as you think. It’s thought to affect anywhere from
There are lots of options for ED pills that are Food and Drug Administration (FDA) approved and relatively safe to take, but you must always consider any potential side effects you may experience due to medication, medical conditions, or other health conditions.
Always talk with a healthcare professional before starting any medication or supplement.
Read on to learn more about FDA-approved ED pills, possible side effects to keep in mind, and safe ways to buy ED pills online.
The short of it ...
Vardenafil (Levitra) is thought to have the least side effects* of all the FDA-approved ED pills available.
*The side effects you experience can vary based on your overall health, other medications you take, and your diet and lifestyle.
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Most phosphodiesterase type 5 (PDE5) inhibitors are safe to take.
However, you’ll still want to discuss using them with a healthcare professional beforehand. This is because certain medical conditions can raise your risk of side effects. Additionally, certain medications can interact with ED pills and increase your risk of side effects.
Viagra can lower your blood pressure after you take it. It’s not a common side effect, but low blood pressure can have symptoms like fatigue, dizziness, and lightheadedness.
Low blood pressure can also be dangerous if you have heart disease. In addition, it can contribute to a heart attack or stroke if you’re also taking nitrates or riociguat (Adempas).
Cialis (tadalafil) has a higher risk of side effects if you drink grapefruit juice or large amounts of alcohol.
Grapefruit juice can cause levels of Cialis to get too high in your bloodstream, and alcohol can make it harder for you to get an erection. Cialis can also interact with nitrates or alpha-blockers for high blood pressure.
Nonprescription ED pills can be dangerous
The
Our Medical Standards and Insights team has carefully researched and vetted over 11,000 products and services. We evaluate services for consistency with standards of care and best practices, and we look into each brand’s reputation before sharing products and services on Healthline.
To choose the services on this page, we considered all the ED treatment services that passed our vetting process. Then, we scored each service to narrow down our list even further.
Four ED medications have been vetted and approved by the FDA. This means that they’re generally safe to use, but they may still have some minor risks or side effects.
Sildenafil (Viagra)
Sildenafil (Viagra) is a type of ED medication called a PDE5 inhibitor.
When you get an erection, your body releases a protein called cyclic guanosine monophosphate (cGMP). This helps widen your blood vessels so blood can flow into your penis and harden the soft, spongy tissues called the corpora cavernosa and corpus spongiosum.
The enzyme PDE5 then breaks down cGMP and restricts blood flow to soften your penis — usually after you ejaculate.
But with ED, PDE5 might break down cGMP too quickly and make it harder for you to get or keep an erection. PDE5 inhibitors like sildenafil help slow down PDE5 as it breaks down cGMP, making it easier to get hard and stay hard.
Most of the time, you’ll be able to get an erection 30 to 60 minutes after taking a typical dose of about 50 milligrams (mg). Once it starts working, sildenafil lasts for about 4 to 6 hours.
Vardenafil (Levitra)
Vardenafil (Levitra) is also a PDE5 inhibitor. It works in the same way as the other FDA-approved ED pills by helping increase blood flow into your penis so that the soft tissues can get and stay hard.
This medication is also sometimes used to treat pulmonary hypertension because of the way it works on the blood vessels in your lungs.
A typical dose of vardenafil — about 10 mg — takes about 60 minutes to start taking effect. If you’re over age 65, a healthcare professional might recommend that you take a lower dose of 5 mg.
Vardenafil lasts a little longer than sildenafil — about 5 to 7 hours per dose.
Tadalafil (Cialis)
Tadalafil (Cialis) is another PD-5 inhibitor, similar to sildenafil and vardenafil.
PDE5 inhibitors can also affect nitric oxide (NO) in your body. NO is involved in helping relax blood vessels that allow blood to flow more easily into your penis.
Tadalafil is also sometimes used to treat benign prostatic hyperplasia (BPH), or enlarged prostate, because it
A typical dose of tadalafil is about 10 mg and starts working after about 30 minutes. In some cases, you may need to wait up to 4 hours before you start noticing the effects. After that, tadalafil can remain in your system for 24 to 36 hours before it stops working.
Tadalafil is also sometimes given in a 2.5-mg or 5-mg daily dose. This can be taken whether sexual activity is planned or not.
Avanafil (Stendra)
Avanafil is a newer form of PDE5 inhibitor similar to the other available ED medications. Unlike other ED medications, there’s no generic version. So, it might be a little more expensive than the others.
A single dose of about 50 to 100 mg usually starts working in about 30 to 45 minutes.
Chewable ED medications are an alternative to pills. Chewable medications are compounded drugs, which are medications that have been changed in some way to meet a particular need (in this case, making them chewable).
While the active ingredients in chewable ED pills are the same as the active ingredients in traditional ED pills, it’s important to know that chewable ED pills are not FDA approved. The
Additionally, chewable ED pills don’t always work as quickly or last as long because they need to be metabolized in your digestive tract.
ED pills are generally safe for most people to take. But there’s still some risk of side effects, including:
- headache
- flushing (reddish skin)
- upset stomach
- stuffy or runny nose
- cold-like symptoms
- nasal congestion
- back pain
- nausea
- rash
- heartburn
It’s wise to seek immediate medical help if you experience any of the following severe side effects:
- allergic reaction
- amnesia
- chest pain
- an erection that lasts more than 4 hours (priapism)
- ringing in the ears (tinnitus)
- dizziness
- muscle pain (myalgia) that doesn’t go away
- vomiting or diarrhea that lasts for more than a day
- hearing loss
- heart palpitation
- irregular heartbeat
- severe low blood pressure
- vision loss
A doctor can prescribe ED pills after an in-person visit. However, if you prefer, you can also get them online from a telemedicine company. They provide access to brand-name and generic versions of FDA-approved ED pills.
These retailers also offer medical services that can help you get in touch with a doctor who can walk you through the process, safety, and side effects of taking ED pills.
Although generic versions contain the same active ingredients to treat ED, some of the other ingredients may be slightly different depending on how the pills are manufactured.
Still, there’s no evidence that brand-name ED pills work any better than their generic versions.
Vardenafil (Levitra)?is thought to have the least side effects out of all the FDA-approved ED pills available.
Keep in mind that the side effects you experience might vary based on your overall health, other medications you’re taking, and your diet and lifestyle.
Viagra and other FDA-approved ED pills are considered safe to take. But all are known to cause side effects in some people, especially at higher doses or when other medications interact with the ED pills.
You can talk with a healthcare professional about what ED pill might be safest for you based on your overall health.
ED pills typically take between 30 and 60 minutes to start working.
This timing can vary depending on when you’ve eaten, how long it’s been since the last time you took an ED pill, and how aroused you are when you take it.
ED pills have a high success rate for most people.
But they may not work well — or even be safe to take — if you’re taking nitrates for chest pain or medications for high blood pressure.
ED pills may also not work if your ED is caused by conditions like anxiety that can result in ED even if you’re not experiencing any physiological issues related to your erections.
Research from 2021 suggests that all PDE5 inhibitors are generally safe for people with diabetes to take.
ED pills are generally safe for most people to take.
But keep in mind that they can have side effects. You can talk with a healthcare professional before you start taking them. They can help make sure they’re safe for you, especially if you have any medical conditions or are taking any other medications that might cause side effects.